Hey Kram if your looking for the best bang for the buck and plan to overclock a low end Core 2 Duo with good ram is the way to go. But if your not looking to overclock stick with an e6600 and some cheaper ram.
On to another question at hand, the board you pick is important for max fsb. For max fsb I like the asus p5b deluxe. And as for timings stick to 4-4-4-12 if you can.
Check out this thread if you want to know how an e6300 and good ram will do on air and watering cooling.